SkinCeuticals P-TIOX Anti-Wrinkle Cream

• Visibly reduces deep set wrinkles + pores that neurotoxins alone do not treat*
• Up to -33% visible wrinkles, -30% pore size​
• Boosts hydration by up to +94% in just 1 hour
• Physician tested to complement neurotoxin injections
• Suitable for all skin types and tones, even sensitive skin
• Smooths skin texture with patent-pending Myrixin™ and advanced peptides
• Achieves glass skin appearance when paired with P-TIOX serum
• TSA-approved

Prep + Dispense

Twice daily, after applying a corrective serum, dispense a small amount into clean hands.

Apply + Complete

Gently press cream evenly into skin on face, neck and around the eyes. Follow with a SkinCeuticals sunscreen.

10% Myrixin™, 2% Tripeptide, 1% Crystalide Micropeptide, 5% Niacinamide + LHA + Zinc PCA 

Full Ingredients:

AQUA / WATER / EAU ● BUTYLENE GLYCOL ● NIACINAMIDE ● GLYCERIN ● DICAPRYLYL CARBONATE ● PENTYLENE GLYCOL ● CETEARYL ALCOHOL ● 1,2-HEXANEDIOL ● ISODODECANE ● C14-22 ALCOHOLS ● CAPRYLIC/CAPRIC TRIGLYCERIDE ● VINYL DIMETHICONE ● MACADAMIA INTEGRIFOLIA SEED OIL ● GLYCERYL STEARATE SE ● C12-20 ALKYL GLUCOSIDE ● NYMPHAEA ALBA FLOWER EXTRACT ● ACRYLATES/C10-30 ALKYL ACRYLATE CROSSPOLYMER ● BUTYROSPERMUM PARKII BUTTER / SHEA BUTTER ● C12-16 ALCOHOLS ● TROMETHAMINE ● PSIDIUM GUAJAVA FRUIT EXTRACT ● CAMELLIA SINENSIS LEAF EXTRACT ● ALLIUM SATIVUM BULB EXTRACT / GARLIC BULB EXTRACT ● ZINC PCA ● CAPRYLOYL SALICYLIC ACID ● PSIDIUM GUAJAVA LEAF EXTRACT ● LUFFA CYLINDRICA FRUIT EXTRACT ● HYDROGENATED LECITHIN ● PALMITIC ACID ● CETYL PALMITATE ● ETHYLHEXYLGLYCERIN ● ADENOSINE ● SORBITAN STEARATE ● POLYSORBATE 80 ● TOCOPHEROL ● CERAMIDE NP ● DIPEPTIDE DIAMINOBUTYROYL BENZYLAMIDE DIACETATE ● SODIUM BENZOATE ● CITRIC ACID ● PALMITOYL TETRAPEPTIDE-10

Clinically tested to visibly correct wrinkles and pores, and improve7 skin quality parameters.

In 1 use*: Hydration is boosted by +94% in just 1 hour and provides 24-hourlong-lasting hydration. Skin barrier is strengthened by +32%.Sebum accumulation is reduced by 50% after 8 hours vs. untreated control.

In 4 weeks**: Skin is visibly smoother by +15% and brighter by +10%.

In 12 weeks***: Wrinkles are visibly reduced, 7 skin quality parametersare visibly improved including elasticity, radiance, smoothnessand tone evenness.

• Up to -33% wrinkles
• Up to -30% pore visibility
• Up to +20% overall skin quality
• Up to +30% skin smoothness​
• Up to +30% skin tone evenness​

Pair P-TIOX Cream with P-TIOX Serum for glass skin results in 1 week.

Physician-tested with neurotoxin injections:
Pair P-TIOX Cream with your in-office neurotoxin injectionsto visibly reduce wrinkles even in non-injected areas.
Tested on all skin tones and types.

How does P-TIOX Cream work?

P-TIOX Cream uses a patented combination of proprietary Myrixin™ and tripeptide technologies to visibly reduce deep-set wrinkles, refine texture, and help minimize the appearance of enlarged pores. Myrixin™ helps modulate oil activity, while the tripeptide supports structural firmness and surface smoothness.

This protective gel cream contains water-bursting micro-droplets that melt into the skin for rapid absorption, delivering instant smoothing and visible texture correction.

How long does it take for P-TIOX Cream to work?

Visible improvements, such as reduced pore visibility, can be seen in as little as one month. Continued daily use helps improve the appearance of deep-set wrinkles and refine overall texture. For optimal results, P-TIOX Cream should be used consistently and paired with P-TIOX serum to support the full glass skin routine.

Can you use P-TIOX Cream with retinol?

Yes, P-TIOX Cream can be used in a routine that includes retinol. During your nighttime routine, apply P-TIOX cream after the retinol. As with any skincare combination, monitor skin tolerance and consult your skincare professional if needed.

Can you use P-TIOX Cream under the eyes?

Yes, you can apply P-TIOX Cream around the eyes. Follow the instructions to apply the cream twice daily to face, neck, and around the eyes. Clinical testing for P-TIOX Cream showed -28% under eye line correction.

Is P-TIOX Cream suitable for men’s skin?

Yes. P-TIOX Cream is well-suited for men’s skin, which often exhibits higher oil production, and more visible pores. This anti-wrinkle cream’s patented Myrixin™ and tripeptide technologies help refine texture, reduce pore appearance, and oil production, all common concerns in men’s skincare.

The lightweight, non-greasy formula melts into the skin, absorbing quickly and supporting smoother, clearer skin without heaviness. This makes it an effective daily moisturizer for men seeking visible improvement in skin clarity and surface refinement.

What are the key differences between P-TIOX Serum and P-TIOX Cream?

P-TIOX Serum is a concentrated treatment that targets visible expression lines and supports skin smoothness resulting in glass skin radiance with a fluid, transparent formula. P-TIOX Cream complements the serum by addressing pores, deep-set wrinkles, and surface texture while delivering hydration in a fresh cream texture that leaves a non-greasy finish. Used together, they create a complete routine for achieving a glass skin effect.

What is glass skin and how can I achieve it?

Glass skin refers to a complexion that appears visibly smooth, luminous, and poreless. Achieving this look involves skincare that targets texture, clarity, and hydration. P-TIOX Cream helps refine texture and reduce shine, and when paired with P-TIOX Serum, contributes to achieving a visibly radiant, even-toned complexion.

Is P-TIOX Cream safe to use after neurotoxin injections?

Yes. P-TIOX Cream is designed to complement neurotoxin injections by helping prolong visible results and supporting smoother skin texture. It is suitable for post-procedure use, though you should always consult your provider for personalized post-treatment care.